Sortilin as a Regulator of Lipoprotein Metabolism
نویسندگان
چکیده
منابع مشابه
Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism.
RATIONALE The (pro)renin receptor ([P]RR) interacts with (pro)renin at concentrations that are >1000× higher than observed under (patho)physiological conditions. Recent studies have identified renin-angiotensin system-independent functions for (P)RR related to its association with the vacuolar H(+)-ATPase. OBJECTIVE To uncover renin-angiotensin system-independent functions of the (P)RR. MET...
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Genome-wide association studies (GWAS) have been used to identify novel genes and loci that contribute to lipid traits and coronary heart disease (CHD) in a causal manner. A locus on chromosome 1p13, which harbors the gene sortilin-1 (SORT1) encoding the protein sortilin is the locus in the human genome with the strongest association with low-density lipoprotein cholesterol (LDL-C) and is also ...
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ژورنال
عنوان ژورنال: Current Atherosclerosis Reports
سال: 2012
ISSN: 1523-3804,1534-6242
DOI: 10.1007/s11883-012-0248-x